New research suggests that people who discontinue new weight-loss injections like Wegovy and Mounjaro can put back on shed pounds at a significantly accelerated pace than those who end conventional lifestyle plans.
Published data in a prominent health publication shows that while obese people often shed a large proportion of their total mass while using the jabs, the mass comes back at an estimated rate of 0.8 kg per month after stopping.
"People purchasing these drugs need to be cognizant of the risk of quick rebound weight gain when the treatment is stopped," stated expert Dr. Susan Jebb.
Such speed of recovery implies a return to pre-treatment weight within about 18 months.
Comparing Approaches
The research, which looked at dozens of trials involving over 9,000 of participants, contrasted the outcomes of these new drugs with other pills.
Scientists emphasize that people who lose weight through lifestyle changes alone usually have a less rapid creep back—approximately 0.1 kg a month—after stopping.
The Reason for the Fast Regain
Experts suggest the mechanism of the jabs accounts for the accelerated rebound.
These medications imitate a natural hormone called GLP-1, which helps regulate hunger.
"Sustained high doses of GLP-1 levels far above than the body's typical production may cause the body to produce less of its own natural GLP-1, and may also diminish responsiveness to its actions," explained Dr. Adam Collins, a dietetics expert.
"Discontinuation of this medication results in hunger is no longer kept in check, making binge eating much more probable."
A Chronic Disease?
Health authorities recommend the injections for individuals with weight-linked health risks, alongside prescribed lifestyle changes.
A number of clinicians say that, due to the high risk of relapse, the therapy should be considered long-term.
This view is echoed by pharmaceutical companies, who say that the findings "emphasize the long-term nature of excess weight," comparing it to managing conditions like high blood pressure.
Patient Testimonies
Individuals who have come off the jabs explain a intense return of hunger.
"I experienced a trigger activating and you're instantly extremely hungry," described one woman.
This challenge is exacerbated if patients have not established permanent lifestyle or habit changes during therapy.
Growing Use
Survey data indicate that a significant number of adults in the UK have used these injections in the past year, with demand continuing to grow.
- Use is more common among women compared to men.
- The 40s and 50s demographic shows the greatest level of interest.
- A large proportion obtain the medications through private healthcare rather than the NHS.
In conclusion, researchers caution that while GLP-1 drugs are powerful tools for shedding pounds, they are not a standalone fix and lasting health benefits hinges on combined behavioural changes.
